Madecassic acid

Modify Date: 2024-01-03 02:23:59

Madecassic acid structure	Common Name	Madecassic acid
	CAS Number	18449-41-7	Molecular Weight	504.698
	Density	1.2±0.1 g/cm3	Boiling Point	641.7±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₈O₆	Melting Point	270ºC (dec.)
	MSDS	N/A	Flash Point	355.9±28.0 °C

Use of Madecassic acid

Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].

Name	madecassic acid
Synonym	More Synonyms

Description	Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2 TNF-α IL-1β IL-6
References	[1]. Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76(3):251-7.

Density	1.2±0.1 g/cm3
Boiling Point	641.7±55.0 °C at 760 mmHg
Melting Point	270ºC (dec.)
Molecular Formula	C₃₀H₄₈O₆
Molecular Weight	504.698
Flash Point	355.9±28.0 °C
Exact Mass	504.345093
PSA	118.22000
LogP	4.99
Vapour Pressure	0.0±4.3 mmHg at 25°C
Index of Refraction	1.591
Storage condition	2-8°C

Hazard Codes	Xi
Safety Phrases	24/25

Methylbrahmat

CAS#:23140-81-0

Madecassic acid

CAS#:18449-41-7

Literature: Phytochemistry (Elsevier), , vol. 7, p. 1385 - 1393

Precursor 1
CAS#:23140-81-0 Methylbrahmat
DownStream 0

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,5ξ,6β,9ξ,18ξ)-

Brahmanic acid

(2α,3β,5ξ,6β,9ξ,18ξ)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid

6-Hydroxyasiatic acid

6BETA-HYDROXYASIATIC ACID

madecaic acid

(2α,3β,6β)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid

madesica acid

MADESIC ACID

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,6β)-

Madecassicacid

Brahmsaeure

(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-4a(2H)-picenecarboxylic acid

Hydroxy asiaticoside

Brahmic acid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Madecassic acid
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Madecassic acid
Price: ￥Inquiry/5mg
Purity: 96.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Madecassic acid
Price: ￥378.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: madecassic acid
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Madecassic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥1040/1g

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Madecassic acid

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