Aminooxy-PEG2-alcohol

Modify Date: 2024-02-02 14:36:30

Aminooxy-PEG2-alcohol Structure
Aminooxy-PEG2-alcohol structure
Common Name Aminooxy-PEG2-alcohol
CAS Number 185022-12-2 Molecular Weight 121.14
Density N/A Boiling Point N/A
Molecular Formula C4H11NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aminooxy-PEG2-alcohol


Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

 Names

Name Aminooxy-PEG2-alcohol

 Aminooxy-PEG2-alcohol Biological Activity

Description Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog
Target

PEGs

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.

[2]. Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3.

 Chemical & Physical Properties

Molecular Formula C4H11NO3
Molecular Weight 121.14
Storage condition 2-8°C
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