PF-739
Modify Date: 2024-04-09 19:17:08
PF-739 structure
|
Common Name | PF-739 | ||
|---|---|---|---|---|
| CAS Number | 1852452-14-2 | Molecular Weight | 442.896 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23ClN2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-739A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM, potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes; increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle; caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice. |
| Name | PF-739 |
|---|
| Description | A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM, potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes; increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle; caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice. |
|---|---|
| References | References 1. Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK |
| Molecular Formula | C23H23ClN2O5 |
|---|---|
| Molecular Weight | 442.896 |