Bimosiamose disodium

Modify Date: 2024-01-09 08:35:07

Bimosiamose disodium structure	Common Name	Bimosiamose disodium
	CAS Number	187269-60-9	Molecular Weight	906.875
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₆H₅₂Na₂O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bimosiamose disodium

Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].

Name	Bimosiamose disodium
Synonym	More Synonyms

Description	Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1]
In Vitro	Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].
In Vivo	Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1] Dosage: 25 mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls.
References	[1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.