ML 179

Modify Date: 2024-01-13 19:26:29

ML 179 Structure
ML 179 structure
Common Name ML 179
CAS Number 1883548-87-5 Molecular Weight 422.44
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H25F3N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML 179


ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1].

 Names

Name ML-179
Synonym More Synonyms

 ML 179 Biological Activity

Description ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1].
Related Catalog
Target

LRH-1[1]

References

[1]. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2). 2010 Oct 12 [updated 2011 Dec 12].

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C21H25F3N4O2
Molecular Weight 422.44
Exact Mass 422.192963
LogP 4.80
Index of Refraction 1.568

 Synonyms

2,4(1H,3H)-Pyrimidinedione, 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-
3-Cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]-1-piperazinyl}-2,4(1H,3H)-pyrimidinedione
3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-1H-pyrimidine-2,4-dione
ML-179
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