ML 67-33

Modify Date: 2023-02-14 15:54:01

ML 67-33 structure	Common Name	ML 67-33
	CAS Number	1443290-89-8	Molecular Weight	374.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₇Cl₂N₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 67-33

ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

Name	ML67-33

Description	ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].
Target	EC50: 36.3 μM (K2P2.1 (TREK-1)), 9.7 μM (K2P2.1 (TREK-1), in HEK293 cells)[1].
In Vitro	ML67-33 activates K2P channels and mutants with EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively[1].
References	[1]. Bagriantsev SN, et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K_2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.

Molecular Formula	C₁₈H₁₇Cl₂N₅
Molecular Weight	374.27

DC Chemicals Limited
China
Product Name: ML67-33
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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ML 67-33

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