ML 354

Modify Date: 2024-01-10 12:54:18

ML 354 structure	Common Name	ML 354
	CAS Number	89159-60-4	Molecular Weight	282.29400
	Density	1.29g/cm3	Boiling Point	544ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₄N₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	282.8ºC
	Symbol	GHS06	Signal Word	Danger

Use of ML 354

ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].

Name	(1-methyl-5-nitro-3-phenylindol-2-yl)methanol
Synonym	More Synonyms

Description	ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
References	[1]. Wen W, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713.

Density	1.29g/cm3
Boiling Point	544ºC at 760 mmHg
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.29400
Flash Point	282.8ºC
Exact Mass	282.10000
PSA	70.98000
LogP	3.76900
Index of Refraction	1.646

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

2-(bromomethyl)-1-methyl-5-nitro-3-phenylindole structure

2-(bromomethyl)...

CAS#:89173-89-7

~74%

ML 354 Structure

ML 354

CAS#:89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

2-methyl-3-phenyl-5-nitroindole structure

2-methyl-3-phen...

CAS#:41018-87-5

~%

ML 354 Structure

ML 354

CAS#:89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

1,2-dimethyl-5-nitro-3-phenylindole structure

1,2-dimethyl-5-...

CAS#:68285-93-8

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ML 354 Structure

ML 354

CAS#:89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

benzyl methyl ketone p-nitrophenylhydrazone structure

benzyl methyl k...

CAS#:70063-29-5

~%

ML 354 Structure

ML 354

CAS#:89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

Precursor 4
CAS#:89173-89-7 2-(bromomethyl)... CAS#:41018-87-5 2-methyl-3-phen... CAS#:68285-93-8 1,2-dimethyl-5-... CAS#:70063-29-5 benzyl methyl k...
DownStream 2
CAS#:84858-14-0 1-methyl-5-nitr... CAS#:84858-15-1 N-[(1-methyl-5-...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-methyl-2-hydroxymethyl-3-phenyl-5-nitroindole

1h-indole-2-methanol,1-methyl-5-nitro-3-phenyl

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ML-354
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ML354
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: ML354
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
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Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CHEMBRDG-BB 5280909
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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