ML-SA5
Modify Date: 2024-01-12 15:43:30
ML-SA5 structure
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Common Name | ML-SA5 | ||
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| CAS Number | 2418670-70-7 | Molecular Weight | 457.995 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 600.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H24ClN3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 316.9±34.3 °C | |
Use of ML-SA5ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can tumour growth[1]. |
| Name | N'-[3-Chloro-2-(1-piperidinyl)phenyl]-N,N-dimethyl-1,4-benzenedisulfonamide |
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| Synonym | More Synonyms |
| Description | ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can tumour growth[1]. |
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| Related Catalog | |
| In Vitro | ML-SA5(1-100 μM, 24 h) 具有一定的细胞靶向特异性，在 M12 和 MeWo 细胞中可诱导大量细胞死亡，但完全保留正常黑素细胞。ML-SA5 还会导致 M12 细胞中线粒体膜电位的丧失[1]。 |
| In Vivo | ML-SA5（静脉注射，2-5 mg/kg，每天，2 周）可使 MDX 小鼠的肌肉坏死减少70%以上，并减少中心有核纤维，表明 ML-SA5 可通过促进肌球蛋白修复来改善 mdx 小鼠体内的肌肉萎缩，但对 ML1 基因敲除小鼠没有作用。此外，ML-SA5 可以通过ML1 上调减少 mdx 小鼠的骨骼和心肌损伤[2]。 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 600.4±65.0 °C at 760 mmHg |
| Molecular Formula | C19H24ClN3O4S2 |
| Molecular Weight | 457.995 |
| Flash Point | 316.9±34.3 °C |
| Exact Mass | 457.089661 |
| LogP | 4.73 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.623 |
| N'-[3-Chloro-2-(1-piperidinyl)phenyl]-N,N-dimethyl-1,4-benzenedisulfonamide |
| 1,4-Benzenedisulfonamide, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl- |