ML 311

Modify Date: 2024-02-26 13:23:51

ML 311 structure	Common Name	ML 311
	CAS Number	315698-17-0	Molecular Weight	415.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₄F₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 311

ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.

Name	ML311

Description	ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1 Bim
In Vitro	ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1].
References	[1]. Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.

Molecular Formula	C₂₃H₂₄F₃N₃O
Molecular Weight	415.45
Storage condition	2-8℃

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ML311
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ML311
Price: $650.0/100mg $1150.0/250mg $2300.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ML311
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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ML 311 suppliers

Price: ￥1210/10 mM * 1 mL in DMSO

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