ML-162
Modify Date: 2024-01-09 15:20:46
ML-162 structure
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Common Name | ML-162 | ||
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| CAS Number | 1035072-16-2 | Molecular Weight | 477.403 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 699.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H22CI2N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 376.7±31.5 °C | |
Use of ML-162A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells. |
| Name | 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide |
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| Synonym | More Synonyms |
| Description | A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells. |
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| References | References 1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Ras |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 699.3±55.0 °C at 760 mmHg |
| Molecular Formula | C23H22CI2N2O3S |
| Molecular Weight | 477.403 |
| Flash Point | 376.7±31.5 °C |
| Exact Mass | 476.072815 |
| LogP | 4.00 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.630 |
| 2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(2-thienyl)ethyl}acetamide |
| 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide |
| 2-Thiopheneacetamide, α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)- |