Actinomycin X2

Modify Date: 2024-01-11 15:27:09

Actinomycin X2 Structure
Actinomycin X2 structure
 Common Name Actinomycin X2
CAS Number 18865-48-0 Molecular Weight 1269.40000
Density 1.44g/cm3 Boiling Point 1411.4ºC at 760mmHg
Molecular Formula C62H84N12O17 Melting Point N/A
MSDS N/A Flash Point 807.4ºC

 Use of Actinomycin X2


Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1].

 Names

Name actinomycin v
Synonym More Synonyms

 Actinomycin X2 Biological Activity

Description Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1].
Related Catalog
References

[1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.

 Chemical & Physical Properties

Density 1.44g/cm3
Boiling Point 1411.4ºC at 760mmHg
Molecular Formula C62H84N12O17
Molecular Weight 1269.40000
Flash Point 807.4ºC
Exact Mass 1268.61000
PSA 377.05000
LogP 1.55260
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.661

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU2010000
CHEMICAL NAME :
Actinomycin X2
CAS REGISTRY NUMBER :
18865-48-0
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C62-H84-N12-O17
MOLECULAR WEIGHT :
1269.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980

 Safety Information

Hazard Codes T+: Very toxic;
Risk Phrases 26/27/28-63
Safety Phrases 22-36/37/39-45
RIDADR UN 2811 6.1/PG 2

 Synonyms

5'-Deoxy(Methylthio-d3)adenosine
3h-phenoxazine,actinomycindderiv.
[A3-(4-oxo-L-proline)]-actinomycin-D
5'-S-(Methyl-d3)thioadenosine
3a-(4-oxo-l-proline)-actinomycin
5'-(Methylthio-d3)adenosine
actinomycin-V
ACTINOMYCIN X2
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