Helioxanthin

Modify Date: 2024-01-02 17:01:52

Helioxanthin Structure
Helioxanthin structure
 Common Name Helioxanthin
CAS Number 18920-47-3 Molecular Weight 348.31
Density 1.5±0.1 g/cm3 Boiling Point 622.5±55.0 °C at 760 mmHg
Molecular Formula C20H12O6 Melting Point N/A
MSDS N/A Flash Point 277.1±31.5 °C

 Use of Helioxanthin


Helioxanthin (ACH126447) and its analogues exhibit significant in vitro antiviral activity against hepatitis B virus (HBV, EC50=1 uM) and flavivirus.IC50 value: 1/3/2 uM (EC50, HBV/HCV/HSV-1) [1]Target: Anti-HBV; Anti flavivirusin vitro: Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model [2]. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells [3].

 Names

Name 10-(1,3-benzodioxol-5-yl)-9H-[2]benzofuro[6,5-g][1,3]benzodioxol-7-one
Synonym More Synonyms

 Helioxanthin Biological Activity

Description Helioxanthin (ACH126447) and its analogues exhibit significant in vitro antiviral activity against hepatitis B virus (HBV, EC50=1 uM) and flavivirus.IC50 value: 1/3/2 uM (EC50, HBV/HCV/HSV-1) [1]Target: Anti-HBV; Anti flavivirusin vitro: Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model [2]. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells [3].
Related Catalog
References

[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.  

[2]. Cheng, Y. C.; Chou, C. K.; Fu, L.; Kuo, Y. H.; Yeh, S. F.; Zhu, J.;Zhu, Y. Inhibition and treatment of hepatitis B virus andflavivirus by helioxanthin and its analogues. U.S. Patent 6306899 B1, 2001.

[3]. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 622.5±55.0 °C at 760 mmHg
Molecular Formula C20H12O6
Molecular Weight 348.31
Flash Point 277.1±31.5 °C
Exact Mass 348.063385
PSA 63.22000
LogP 3.70
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.723

 Safety Information

HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one
Furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one, 10-(1,3-benzodioxol-5-yl)-
justicidin E
ZHU-IX-139-1
Helioxanthin
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Related Compounds: More...
Helioxanthin 8-1
840529-13-7
Helioxanthin derivative 5-4-2
203935-39-1
Chemsrc provides Helioxanthin(CAS#:18920-47-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Helioxanthin are included as well.>> amp version: Helioxanthin

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