Helioxanthin

Modify Date: 2024-01-02 17:01:52

Helioxanthin structure	Common Name	Helioxanthin
	CAS Number	18920-47-3	Molecular Weight	348.31
	Density	1.5±0.1 g/cm3	Boiling Point	622.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	277.1±31.5 °C

Use of Helioxanthin

Helioxanthin (ACH126447) and its analogues exhibit significant in vitro antiviral activity against hepatitis B virus (HBV, EC50=1 uM) and flavivirus.IC50 value: 1/3/2 uM (EC50, HBV/HCV/HSV-1) [1]Target: Anti-HBV; Anti flavivirusin vitro: Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model [2]. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells [3].

Name	10-(1,3-benzodioxol-5-yl)-9H-[2]benzofuro[6,5-g][1,3]benzodioxol-7-one
Synonym	More Synonyms

Description	Helioxanthin (ACH126447) and its analogues exhibit significant in vitro antiviral activity against hepatitis B virus (HBV, EC50=1 uM) and flavivirus.IC50 value: 1/3/2 uM (EC50, HBV/HCV/HSV-1) [1]Target: Anti-HBV; Anti flavivirusin vitro: Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model [2]. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells [3].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
References	[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46. [2]. Cheng, Y. C.; Chou, C. K.; Fu, L.; Kuo, Y. H.; Yeh, S. F.; Zhu, J.;Zhu, Y. Inhibition and treatment of hepatitis B virus andflavivirus by helioxanthin and its analogues. U.S. Patent 6306899 B1, 2001. [3]. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

References

[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.

[2]. Cheng, Y. C.; Chou, C. K.; Fu, L.; Kuo, Y. H.; Yeh, S. F.; Zhu, J.;Zhu, Y. Inhibition and treatment of hepatitis B virus andflavivirus by helioxanthin and its analogues. U.S. Patent 6306899 B1, 2001.

[3]. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Density	1.5±0.1 g/cm3
Boiling Point	622.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₂O₆
Molecular Weight	348.31
Flash Point	277.1±31.5 °C
Exact Mass	348.063385
PSA	63.22000
LogP	3.70
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.723

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one

Furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one, 10-(1,3-benzodioxol-5-yl)-

justicidin E

ZHU-IX-139-1

Helioxanthin

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Helioxanthin
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Helioxanthin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g ￥220.0/10ml
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Helioxanthin

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