Lopinavir Metabolite M-1

Modify Date: 2024-01-09 18:40:28

Lopinavir Metabolite M-1 structure	Common Name	Lopinavir Metabolite M-1
	CAS Number	192725-39-6	Molecular Weight	642.78400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₄₆N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lopinavir Metabolite M-1

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].

Name	Lopinavir Metabolite M-1
Synonym	More Synonyms

Description	Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 0.7 pM (HIV Protease)[1]
In Vitro	Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC50 of 1.413 μM[1].
References	[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3. [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.

Molecular Formula	C₃₇H₄₆N₄O₆
Molecular Weight	642.78400
Exact Mass	642.34200
PSA	137.07000
LogP	5.63440
Index of Refraction	1.582

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(2S,3S,5S)-2-(2...

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~81%

Lopinavir Metab...

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Literature: Sham, Hing L; Betebenner, David A; Herrin, Thomas; Kumar, Gondi; Saldivar, Ayda; Vasavanonda, Sudthida; Molla, Akhter; Kempf, Dale J; Plattner, Jacob J; Norbeck, Daniel W Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1351 - 1353

tert-Butyl L-va...

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(S)-2-(2,4-diox...

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Lopinavir Metab...

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Precursor 6
CAS#:192725-49-8 (2S,3S,5S)-2-(2... CAS#:13211-31-9 tert-Butyl L-va... CAS#:13335-71-2 2,6-Dimethylphe... CAS#:192725-86-3 N-(3-Methoxy-3-...
CAS#:192725-87-4 N-(3-Propanamid... CAS#:192725-88-5 (S)-2-(2,4-diox...
DownStream 0

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane

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4-Oxo-ABT-378