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192725-39-6

192725-39-6 structure
192725-39-6 structure
  • Name: Lopinavir Metabolite M-1
  • Chemical Name: Lopinavir Metabolite M-1
  • CAS Number: 192725-39-6
  • Molecular Formula: C37H46N4O6
  • Molecular Weight: 642.78400
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Protease
  • Create Date: 2016-02-06 13:41:35
  • Modify Date: 2024-01-09 18:40:28
  • Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Name Lopinavir Metabolite M-1
Synonyms (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d
4-Oxo-ABT-378
Description Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Related Catalog
Target

IC50: 0.7 pM (HIV Protease)[1]

In Vitro Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC50 of 1.413 μM[1].
References

[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.

[2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.
Molecular Formula C37H46N4O6
Molecular Weight 642.78400
Exact Mass 642.34200
PSA 137.07000
LogP 5.63440
Index of Refraction 1.582

Chemsrc provides CAS#:192725-39-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 192725-39-6 | Chemsrc address: https://www.chemsrc.com/en/baike/29088.html

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