192725-39-6

192725-39-6 structure

Name: Lopinavir Metabolite M-1
Chemical Name: Lopinavir Metabolite M-1
CAS Number: 192725-39-6
Molecular Formula: C₃₇H₄₆N₄O₆
Molecular Weight: 642.78400
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Protease
Create Date: 2016-02-06 13:41:35
Modify Date: 2024-01-09 18:40:28
Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].

Name	Lopinavir Metabolite M-1
Synonyms	(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-d 4-Oxo-ABT-378

Description	Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 0.7 pM (HIV Protease)[1]
In Vitro	Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC50 of 1.413 μM[1].
References	[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3. [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.

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192725-49-8

~81%

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13211-31-9

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353

13335-71-2

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353

192725-86-3

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353

192725-87-4

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353

192725-88-5

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353