RWJ-49815

Modify Date: 2024-01-28 00:31:46

RWJ-49815 Structure
RWJ-49815 structure
Common Name RWJ-49815
CAS Number 193282-45-0 Molecular Weight 449.598
Density N/A Boiling Point N/A
Molecular Formula C30H31N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RWJ-49815


A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.

 Names

Name RWJ-49815

 RWJ-49815 Biological Activity

Description A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.
References References 1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22. 2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4. 3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37. View Related Products by Target Bacterial

 Chemical & Physical Properties

Molecular Formula C30H31N3O
Molecular Weight 449.598
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