RWJ-49815
Modify Date: 2024-01-28 00:31:46
RWJ-49815 structure
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Common Name | RWJ-49815 | ||
|---|---|---|---|---|
| CAS Number | 193282-45-0 | Molecular Weight | 449.598 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RWJ-49815A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin. |
| Name | RWJ-49815 |
|---|
| Description | A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin. |
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| References | References 1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22. 2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4. 3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37. View Related Products by Target Bacterial |
| Molecular Formula | C30H31N3O |
|---|---|
| Molecular Weight | 449.598 |