Co 101244 hydrochloride

Modify Date: 2024-01-13 19:55:00

Use of Co 101244 hydrochloride

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

Name	1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)
Synonym	More Synonyms

Description	Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1].
In Vivo	Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].
References	[1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.

4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-, hydrochloride (1:1)

1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidin-4-ol hydrochloride (1:1)

1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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