193356-17-1

193356-17-1 structure

Name: Co 101244 hydrochloride
Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)
CAS Number: 193356-17-1
Molecular Formula: C₂₁H₂₈ClNO₃
Molecular Weight: 377.9
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-07-05 07:04:15
Modify Date: 2024-01-13 19:55:00
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

Name	1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)
Synonyms	4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-, hydrochloride (1:1) 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidin-4-ol hydrochloride (1:1) 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)

Description	Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1].
In Vivo	Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].
References	[1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.