SLF

Modify Date: 2024-01-08 11:17:58

SLF structure	Common Name	SLF
	CAS Number	195513-96-3	Molecular Weight	524.648
	Density	1.2±0.1 g/cm3	Boiling Point	656.9±65.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₀N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	351.1±34.3 °C

Use of SLF

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3].

Name	1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimet hyl-2-oxopentanoyl)-2-piperidinecarboxylate
Synonym	More Synonyms

Description	SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3].
Related Catalog	Research Areas >> Cancer
References	[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425. [2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95. [3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Description

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3].

Related Catalog

Research Areas >> Cancer

References

[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.

[2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.

[3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Density	1.2±0.1 g/cm3
Boiling Point	656.9±65.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₀N₂O₆
Molecular Weight	524.648
Flash Point	351.1±34.3 °C
Exact Mass	524.288635
PSA	108.16000
LogP	3.63
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.559
Storage condition	-20°C

(1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-piperidinecarboxylate

2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-

SLF

Use of SLF

Names

SLF Biological Activity

Chemical & Physical Properties

Synonyms