4-Amino-4-deoxy-10-methylpteroic acid
Modify Date: 2024-01-02 14:01:11
4-Amino-4-deoxy-10-methylpteroic acid structure
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Common Name | 4-Amino-4-deoxy-10-methylpteroic acid | ||
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| CAS Number | 19741-14-1 | Molecular Weight | 325.325 | |
| Density | 1.532 | Boiling Point | 689.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C15H15N7O2 | Melting Point | 242 ºC | |
| MSDS | N/A | Flash Point | 370.7±34.3 °C | |
Use of 4-Amino-4-deoxy-10-methylpteroic acidMethotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1]. |
| Name | 4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid |
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| Synonym | More Synonyms |
| Description | Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1]. |
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| Related Catalog | |
| References |
| Density | 1.532 |
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| Boiling Point | 689.3±65.0 °C at 760 mmHg |
| Melting Point | 242 ºC |
| Molecular Formula | C15H15N7O2 |
| Molecular Weight | 325.325 |
| Flash Point | 370.7±34.3 °C |
| Exact Mass | 325.128723 |
| PSA | 144.14000 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.799 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 43-52/53 |
| Safety Phrases | 36/37 |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.
Chem. Biol. 7(5) , 313-21, (2000) Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactio... |
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An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.
Ann. Clin. Biochem. 23 ( Pt 2) , 210-5, (1986)
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The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
Clin. Lab. 57(7-8) , 599-606, (2011) A modified high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of methotrexate (MTX) and its main metabolite 7-hydroxymethotrexate (7-OHMTX) and... |
| Methotrexate impurity E |
| 4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoic acid |
| S1584_Selleck |
| 4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid |
| Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]- |
| 4-{[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino}benzoic acid |
| Deoxyaminopteroic acid |
| DAMPA |
| 4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid |
| 4-Amino-4-deoxy-10-methylpteroic acid |
| Methotrexate Impurity 5 |