Z-FA-FMK

Modify Date: 2024-01-09 15:40:42

Z-FA-FMK Structure
Z-FA-FMK structure
Common Name Z-FA-FMK
CAS Number 197855-65-5 Molecular Weight 386.417
Density 1.2±0.1 g/cm3 Boiling Point 630.5±55.0 °C at 760 mmHg
Molecular Formula C21H23FN2O4 Melting Point N/A
MSDS N/A Flash Point 335.1±31.5 °C

 Use of Z-FA-FMK


Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) is a broad-spectrum halomethyl ketone inhibitor sgainst Coronavirus (SARS-CoV) main protease 3CL with a Ki of 25.7 μM[1].

 Names

Name z-phe-dl-ala-fluoromethylketone
Synonym More Synonyms

 Z-FA-FMK Biological Activity

Description Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) is a broad-spectrum halomethyl ketone inhibitor sgainst Coronavirus (SARS-CoV) main protease 3CL with a Ki of 25.7 μM[1].
Related Catalog
Target

Ki: 25.7 μM (SARS Protease 3CLpro)[1]

References

[1]. Usman Bacha, et al. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 630.5±55.0 °C at 760 mmHg
Molecular Formula C21H23FN2O4
Molecular Weight 386.417
Flash Point 335.1±31.5 °C
Exact Mass 386.164185
PSA 84.50000
LogP 3.67
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.549
Storage condition -15°C

 Synonyms

z-fa-fmk
UNII:34O3P3306Z
Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)phenylalaninamide
Carbamic acid, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
Carbamic acid, N-[2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)-L-phenylalaninamide
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