GAP 27 acetate salt
GAP 27 acetate salt structure
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Common Name | GAP 27 acetate salt | ||
|---|---|---|---|---|
| CAS Number | 198284-64-9 | Molecular Weight | 1304.53000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C60H101N15O17 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of GAP 27 acetate saltGap 27, connexin43 mimetic peptide, is a gap junction inhibitor. |
| Name | Gap 27 |
|---|---|
| Synonym | More Synonyms |
| Description | Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor. |
|---|---|
| Related Catalog | |
| In Vitro | Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished[1]. Incubation of the carotid artery with the gap junction inhibitor Gap 27 (500 μM) essentially abolishes the hyperpolarization to acetylcholine but it is without effect on that to levcromakalim. In the guinea-pig isolated internal carotid artery, Gap 27 inhibits acetylcholine-induced, endothelium-dependent hyperpolarizations[2]. |
| In Vivo | Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta. [3]. |
| Cell Assay | Bone cell cultures are cultured for 48 hours with three different treatments (control, heptanol and Gap 27). After the culture period, bone slices are fixed. The cells are stained for tartrate-resistant acid phosphatase (TRAP). To visualise the nuclei, the cells are incubated with the DNA-binding fluorochrome Hoechst 33258 (1 mg/mL stock diluted 1:800 in PBS) for 10 minutes at room temperature. The numbers of mononuclear and multinucleated TRAP-positive cells on each bone slice are counted[1]. |
| References |
| Molecular Formula | C60H101N15O17 |
|---|---|
| Molecular Weight | 1304.53000 |
| Exact Mass | 1303.75000 |
| PSA | 531.44000 |
| LogP | 2.19200 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22 |
| RIDADR | NONH for all modes of transport |
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Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor.
Circ. Res. 90(10) , 1108-13, (2002) The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is controversial, putatively involving diffusible factors and/or electrotonic spread of hyperpolarization generated in t... |
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Connexin 43 communication channels in follicular dendritic cell development and in follicular lymphomas.
J. Immunol. Res. 2015 , 528098, (2015) Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicula... |
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Connexin-mimetic peptide Gap 27 decreases osteoclastic activity.
BMC Musculoskelet. Disord. 2 , 10, (2003) Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and t... |
| Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile |
| M.W. 1304.55 C60H101N15O17 |
| H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE |
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