Furanodiene

Modify Date: 2024-01-05 13:20:27

Furanodiene Structure
Furanodiene structure
Common Name Furanodiene
CAS Number 19912-61-9 Molecular Weight 216.31900
Density 0.945±0.06 g/cm3 Boiling Point 309.6±11.0 °C at 760 mmHg
Molecular Formula C15H20O Melting Point 74-75 °C
MSDS N/A Flash Point N/A

 Use of Furanodiene


Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].

 Names

Name furanodiene
Synonym More Synonyms

 Furanodiene Biological Activity

Description Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].
Related Catalog
In Vitro Furanodiene (1.4, 4.1, 12.2 uM; 48 hours) is effective in treating human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into the zebrafish[1]. Furanodiene has no effect on Pgp related gene (MDR1) expression[1].
References

[1]. Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541.

 Chemical & Physical Properties

Density 0.945±0.06 g/cm3
Boiling Point 309.6±11.0 °C at 760 mmHg
Melting Point 74-75 °C
Molecular Formula C15H20O
Molecular Weight 216.31900
Exact Mass 216.15100
PSA 13.14000
LogP 4.35940

 Synonyms

cyclodeca(b)furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5e,9z)-