Gefitinib impurity 5

Modify Date: 2024-01-02 14:51:44

Gefitinib impurity 5 Structure
Gefitinib impurity 5 structure
Common Name Gefitinib impurity 5
CAS Number 199327-61-2 Molecular Weight 319.356
Density 1.3±0.1 g/cm3 Boiling Point 564.4±50.0 °C at 760 mmHg
Molecular Formula C16H21N3O4 Melting Point N/A
MSDS N/A Flash Point 295.2±30.1 °C

 Use of Gefitinib impurity 5


Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

 Names

Name 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
Synonym More Synonyms

 Gefitinib impurity 5 Biological Activity

Description Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog
References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 564.4±50.0 °C at 760 mmHg
Molecular Formula C16H21N3O4
Molecular Weight 319.356
Flash Point 295.2±30.1 °C
Exact Mass 319.153198
PSA 76.68000
LogP 0.29
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.611
Storage condition 2~8℃

 Safety Information

Hazard Codes Xi
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]-
7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone
Gefitinib Impurity 17
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