Gefitinib impurity 2

Modify Date: 2024-01-02 10:40:10

Gefitinib impurity 2 Structure
Gefitinib impurity 2 structure
 Common Name Gefitinib impurity 2
CAS Number 246512-44-7 Molecular Weight 309.36100
Density N/A Boiling Point N/A
Molecular Formula C15H23N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Gefitinib impurity 2


Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

 Names

Name 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzamide
Synonym More Synonyms

 Gefitinib impurity 2 Biological Activity

Description Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog
References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

[2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

 Chemical & Physical Properties

Molecular Formula C15H23N3O4
Molecular Weight 309.36100
Exact Mass 309.16900
PSA 101.03000
LogP 1.88070

 Synthetic Route

2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile structure

2-amino-4-metho...

CAS#:675126-27-9

~37%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide structure

4-Methoxy-5-(3-...

CAS#:861453-16-9

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; PULLA REDDY, Muddasani; NAGESHWARA RAO, Bollepalli; VENKAIAH CHOWDARY, Nannapaneni Patent: WO2005/70909 A1, 2005 ; Location in patent: Page/Page column 29 ;
4-(3-Chloropropyl)morpholine structure

4-(3-Chloroprop...

CAS#:7357-67-7

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
3-(3-Morpholinylpropoxy)-4-methoxybenzonitrile structure

3-(3-Morpholiny...

CAS#:675126-28-0

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
Gefitinib impurity 1 structure

Gefitinib impurity 1

CAS#:675126-26-8

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
Isovanillin structure

Isovanillin

CAS#:621-59-0

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
3-Hydroxy-4-methoxybenzonitrile structure

3-Hydroxy-4-met...

CAS#:52805-46-6

~%

Gefitinib impurity 2 Structure

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

 Synonyms

2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide
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