Amiloride hydrochloride structure
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Common Name | Amiloride hydrochloride | ||
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CAS Number | 2016-88-8 | Molecular Weight | 266.088 | |
Density | 2.11 g/cm3 | Boiling Point | 628.1ºC at 760 mmHg | |
Molecular Formula | C6H9Cl2N7O | Melting Point | 293-294°C | |
MSDS | N/A | Flash Point | 333.7ºC |
Use of Amiloride hydrochlorideAmiloride (hydrochloride) is an epithelial sodium channel (ENaC) inhibitor and a competitive inhibitor of Urokinase-type plasminogen activator (uPA). |
Name | amiloride hydrochloride |
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Synonym | More Synonyms |
Description | Amiloride (hydrochloride) is an epithelial sodium channel (ENaC) inhibitor and a competitive inhibitor of Urokinase-type plasminogen activator (uPA). |
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Related Catalog | |
Target |
ENaC, uPA[1] |
In Vitro | Amiloride blocks δβγ channels with an IC50 of 2.6 μM. The Ki of amiloride for δβγ ENaC is 26-fold that of αβγ channels (0.1 μM for αβγ ENaC). Amiloride blockade of δβγ ENaC is much more voltage dependent compared with the αβγ channel. The Ki of amiloride for δαβγ channels is 920 and 13.7 μM at −120 and +80 mV, respectively, which significantly differs from that of both αβγ and δβγ channels[1]. Amiloride is a relatively selective inhibitor of the epithelial sodium channel (ENaC) with an IC50 (the concentration required to reach 50% inhibition of an ion channel) in the concentration range of 0.1 to 0.5 μM. Amiloride is a relatively poor inhibitor of the the Na+/H+ exchanger (NHE) with an IC50 as low as 3 μM in the presence of a low external [Na+] but as high as 1 mM in the presence of a high [Na+]. Amiloride is an even weaker inhibitor of the Na+/Ca2+ exchanger (NCX), with an IC50 of 1 mM. Amiloride (1 μM) and submicromolar doses of Benzamil (30 nM), doses known to inhibit the ENaC, inhibit the myogenic vasoconstriction response to increasing perfusion pressure by blocking the activity of ENaC proteins. Amiloride completely inhibits Na+ influx in doses known to be relatively specific for ENaC (1.5 μM) in vascular smooth muscle cells (VSMC)[2]. |
In Vivo | Amiloride (1 mg/kg/day) subcutaneously is found to reverse the initial increases in collagen deposition and prevent any further increases in the DOCA-salt hypertensive rat. Amiloride delays the onset of proteinuria and improved brain and kidney histologic scores in the saline-drinking, stroke-prone spontaneously hypertensive rats (SHRSP) compared with controls. Amiloride antagonizes or prevents actions of aldosterone in these cells and in cardiovascular and renal tissues in animals with salt-dependent forms of hypertension[2]. |
References |
Density | 2.11 g/cm3 |
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Boiling Point | 628.1ºC at 760 mmHg |
Melting Point | 293-294°C |
Molecular Formula | C6H9Cl2N7O |
Molecular Weight | 266.088 |
Flash Point | 333.7ºC |
Exact Mass | 265.024567 |
PSA | 156.79000 |
LogP | 2.07300 |
Vapour Pressure | 1.08E-15mmHg at 25°C |
Storage condition | Store at RT |
Water Solubility | H2O: 50 mg/mL, clear, yellow-green | <0.1 g/100 mL at 19.5 ºC |
Material Safety Data Sheet
Section1. Identification of the substance Product Name: Amiloride HCl dihydrate Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H301:Toxic if swallowed
P264:Wash thoroughly after handling P270:Do not eat, drink or smoke when using this product P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P321:Specific treatment (see on this label) P405:Store locked up Section3. Composition/information on ingredients. Ingredient name:Amiloride HCl dihydrate CAS number:2016-88-8 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula:C6H8ClN7O.ClH.2H2O Molecular weight:302.1 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information UN Number:UN2811 Class: 6.1 Packing group: III Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (Amiloride HCl dihydrate) Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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HS Code | 2934999090 |
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Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
GUANAMPRAZINE |
amiprazidine |
2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride (1:1) |
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride |
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate |
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Hydrochloride Hydrate |
Amiloridhydrochlorid |
N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride |
AMIPRAMIDIN |
Amiloride HCl |
3,5-Diamino-N-carbamimidoyl-6-chloro-2-pyrazinecarboxamide hydrochloride (1:1) |
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide chlorhydrate |
N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride |
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide hydrochloride |
Arumil |
AMipraMidine |
HCL AMILORIDE HCL |
UNII-7M458Q65S3 |
Midamor |
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride |
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride (1:1) |
AMIPRAMIZIDE |
amiloride monohydrochloride |
amiloridechloride |
Amiloride (hydrochloride) |
Guanamprazine hydrochloride |
AMipraMizi |
EINECS 217-958-2 |
MFCD03703482 |
2-pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride |
Amiloride hydrochloride |