Safinamide Mesylate
Modify Date: 2024-01-02 13:28:50
Safinamide Mesylate structure
|
Common Name | Safinamide Mesylate | ||
|---|---|---|---|---|
| CAS Number | 202825-46-5 | Molecular Weight | 398.449 | |
| Density | N/A | Boiling Point | 476.7ºC at 760 mmHg | |
| Molecular Formula | C18H23FN2O5S | Melting Point | 210° (dec) | |
| MSDS | Chinese USA | Flash Point | 242.1ºC | |
| Symbol |
GHS05, GHS06, GHS09 |
Signal Word | Danger | |
Use of Safinamide MesylateSafinamide mesylate mesylate (FCE 26743 mesylate; EMD 1195686 mesylate) is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3]. |
| Name | Safinamide mesylate salt |
|---|---|
| Synonym | More Synonyms |
| Description | Safinamide mesylate mesylate (FCE 26743 mesylate; EMD 1195686 mesylate) is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3]. |
|---|---|
| Related Catalog | |
| Target |
MAO-B:98 nM (IC50) MAO-A:580 nM (IC50) |
| In Vitro | Safinamide mesylate (1-300 µM) reduces the amplitude of the peak sodium currents in a concentration-dependent manner. When currents are stimulated to a Vtest of +10 mV from a Vh of -110 mV, the IC50 value was 262 µM. When the holding potential is depolarized to -53 mV, the inhibitory effect of Safinamide mesylate with a lower IC50 value (8 µM) in rat cortical neurons[1]. |
| In Vivo | Safinamide mesylate (intraperitoneal injection; 90 mg/kg; once daily; 14 days) treatment prior to MCAO significantly ameliorates MCAO-caused cerebral infarction volume, neurological deficit, disruption of the brain-blood barrier (BBB), and impairs expression of tight junction protein occludin and ZO-1 in mice[3]. Safinamide mesylate (intraperitoneal injection; 5 mg/kg, 15 mg/kg and 30 mg/kg) dose dependently inhibits the veratridine-induced GABA release and Glu release in vivo. At the dose 30 mg/kg, Safinamide mesylate prevents the effect of veratridine both on Glu (treatment F1,8=1.31; time×treatment interaction F8,64=2.4) and GABA (treatment F1,8=4.04; time F8,64=3.76, time×treatment interaction F8,64=2.83) release. Safinamide mesylate causes a slight, albeit not significant, reduction of veratridine-stimulated Glu release at 0.5 mg/kg and full inhibition at 5 and 15 mg/kg in rat[3]. |
| References |
| Boiling Point | 476.7ºC at 760 mmHg |
|---|---|
| Melting Point | 210° (dec) |
| Molecular Formula | C18H23FN2O5S |
| Molecular Weight | 398.449 |
| Flash Point | 242.1ºC |
| Exact Mass | 398.131165 |
| PSA | 127.10000 |
| LogP | 4.04410 |
| Vapour Pressure | 2.98E-09mmHg at 25°C |
| Symbol |
GHS05, GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H318-H400 |
| Precautionary Statements | P273-P280-P301 + P310-P305 + P351 + P338 |
| Hazard Codes | C |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2924299090 |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide |
| N-{4-[(3-Fluorobenzyl)oxy]benzyl}-L-alaninamide methanesulfonate (1:1) |
| Propanamide, 2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-, methanesulfonate (1:1) |
| (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide,methanesulfonic acid |
| PNU-151774E,NW-1015 |
| Safinamide mesylate |
| (S)-2-(4-(3-fluorobenzyloxy)benzylamino)propanamide,methanesulfonate |
| (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide |
| FCE-28073(R-isomer),PNU-151774E,NW-1015 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Safinamide Mesylate
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Safinamide Mesylate
- Price: ￥1218.0/10mg ￥4288.0/50mg ￥768.0/5mg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Safinamide mesylate
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Safinamide mesylate
- Price: $400.0/100mg $700.0/250mg $1300.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (S)-2-((4-((3-FLUOROBENZYL)OXY)BENZYL)AMINO)PROPANAMIDE METHANESULFONATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
Get all suppliers and price by the below link:
Price: ￥800/10 mg
Reference only. check more Safinamide Mesylate price