Mutated EGFR-IN-2

Modify Date: 2024-01-12 13:12:55

Mutated EGFR-IN-2 structure	Common Name	Mutated EGFR-IN-2
	CAS Number	2050906-97-1	Molecular Weight	562.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₅FN₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mutated EGFR-IN-2

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].

Name	Mutated EGFR-IN-2

Description	Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRT790M EGFRL858R EGFRex19del EGFR (L858R/T790M):<1 nM (IC50) EGFR (ex19del/T790M)
References	[1]. 2, 4-di-(nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.

Molecular Formula	C₂₉H₃₅FN₈O₃
Molecular Weight	562.64

Shanghai Nianxing Industrial Co., Ltd
China
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