2050906-97-1
2050906-97-1 structure
- Name: Mutated EGFR-IN-2
- Chemical Name: Mutated EGFR-IN-2
- CAS Number: 2050906-97-1
- Molecular Formula: C29H35FN8O3
- Molecular Weight: 562.64
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2019-09-09 19:27:48
- Modify Date: 2024-01-12 13:12:55
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Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].
| Name | Mutated EGFR-IN-2 |
|---|
| Description | Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFRT790M EGFRL858R EGFRex19del EGFR (L858R/T790M):<1 nM (IC50) EGFR (ex19del/T790M) |
| References |
| Molecular Formula | C29H35FN8O3 |
|---|---|
| Molecular Weight | 562.64 |