Tubulysin B
Modify Date: 2024-01-08 17:45:03
Tubulysin B structure
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Common Name | Tubulysin B | ||
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| CAS Number | 205304-87-6 | Molecular Weight | 830.042 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 978.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H63N5O10S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 545.3±34.3 °C | |
Use of Tubulysin BTubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2]. |
| Name | Tubulysin B |
|---|---|
| Synonym | More Synonyms |
| Description | Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2]. |
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| Related Catalog | |
| In Vitro | Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 978.0±65.0 °C at 760 mmHg |
| Molecular Formula | C42H63N5O10S |
| Molecular Weight | 830.042 |
| Flash Point | 545.3±34.3 °C |
| Exact Mass | 829.429565 |
| LogP | 5.78 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.552 |
| (2S,4R)-4-[({2-[(1R,3R)-1-Acetoxy-3-{[(butyryloxy)methyl](N-{[(2R)-1-methyl-2-piperidinyl]carbonyl}-L-isoleucyl)amino}-4-methylpentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid |
| Tubulysin B |
| Pentanoic acid, 4-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-5-(4-hydroxyphenyl)-2-methyl-, (2S,4R)- |