E3 Ligand-Linker Conjugate 4

Modify Date: 2024-01-02 08:57:44

E3 Ligand-Linker Conjugate 4 Structure
E3 Ligand-Linker Conjugate 4 structure
 Common Name E3 Ligand-Linker Conjugate 4
CAS Number 2093388-45-3 Molecular Weight 329.39
Density N/A Boiling Point N/A
Molecular Formula C18H23N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of E3 Ligand-Linker Conjugate 4


E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1].

 Names

Name E3 ligase Ligand 9

 E3 Ligand-Linker Conjugate 4 Biological Activity

Description E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1].
Related Catalog
Target

E3 ligase[1].

References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

 Chemical & Physical Properties

Molecular Formula C18H23N3O3
Molecular Weight 329.39
Storage condition 2-8℃
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Chemsrc provides E3 Ligand-Linker Conjugate 4(CAS#:2093388-45-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of E3 Ligand-Linker Conjugate 4 are included as well.>> amp version: E3 Ligand-Linker Conjugate 4

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