Vatalanib succinate

Modify Date: 2024-01-29 19:13:29

Vatalanib succinate structure	Common Name	Vatalanib succinate
	CAS Number	212142-18-2	Molecular Weight	464.90
	Density	N/A	Boiling Point	587.8ºC at 760 mmHg
	Molecular Formula	C₂₄H₂₁ClN₄O₄	Melting Point	195ºC
	MSDS	N/A	Flash Point	309.3ºC

Use of Vatalanib succinate

Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1].

Name	butanedioic acid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
Synonym	More Synonyms

Description	Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	KDR:37 nM (IC50) Flt-1:77 nM (IC50) Flt-4:730 nM (IC50)
References	[1]. J M Wood, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60(8):2178-89.

Boiling Point	587.8ºC at 760 mmHg
Melting Point	195ºC
Molecular Formula	C₂₄H₂₁ClN₄O₄
Molecular Weight	464.90
Flash Point	309.3ºC
Exact Mass	464.125122
PSA	125.30000
LogP	5.02140
Vapour Pressure	8.48E-14mmHg at 25°C

N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1)

PTK787

1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate

Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1)

1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1)

N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate

N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1)

(4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate

N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1)

(4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate

Vatalanib

T66 CNNJ BMR DG& E1- DT6NJ &&Succinate

Vatalanib succinate

PTK/ZK

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vatalanib succinate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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