BIRT 377

Modify Date: 2024-01-11 16:32:04

BIRT 377 Structure
BIRT 377 structure
Common Name BIRT 377
CAS Number 213211-10-0 Molecular Weight 442.13
Density 1.6±0.1 g/cm3 Boiling Point 518.8±60.0 °C at 760 mmHg
Molecular Formula C18H15BrCl2N2O2 Melting Point N/A
MSDS N/A Flash Point 267.6±32.9 °C

 Use of BIRT 377


BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

 Names

Name BIRT 377
Synonym More Synonyms

 BIRT 377 Biological Activity

Description BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].
Related Catalog
Target

Ki: 25.8 nM (LFA-1)[1]

References

[1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 518.8±60.0 °C at 760 mmHg
Molecular Formula C18H15BrCl2N2O2
Molecular Weight 442.13
Flash Point 267.6±32.9 °C
Exact Mass 439.969391
LogP 4.76
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.632

 Synonyms

(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-, (5R)-
(5R)-5-(4-Bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
(5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione
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