7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

Modify Date: 2024-10-05 02:21:29

7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl- structure	Common Name	7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-
	CAS Number	2133-80-4	Molecular Weight	284.23
	Density	2.49g/cm3	Boiling Point	567.3ºC at 760 mmHg
	Molecular Formula	C₉H₁₂N₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	296.9ºC

Use of 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

8-Azaguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	8-Azaguanosine
Synonym	More Synonyms

Description	8-Azaguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	2.49g/cm3
Boiling Point	567.3ºC at 760 mmHg
Molecular Formula	C₉H₁₂N₆O₅
Molecular Weight	284.23
Flash Point	296.9ºC
Exact Mass	284.08700
PSA	172.40000
Vapour Pressure	3.13E-15mmHg at 25°C
Index of Refraction	2.059

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ6157200

CHEMICAL NAME :: 7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-3,6-dihydro-3-beta-D-ribofuranosyl

CAS REGISTRY NUMBER :: 2133-80-4

BEILSTEIN REFERENCE NO. :: 0046037

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H12-N6-O5

MOLECULAR WEIGHT :: 284.27

WISWESSER LINE NOTATION :: T56 BNNN FVM INJ HZ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970

8-Aza-guanosin

9-ss-D-ribofuranosyl-8-aza-guanin

Azaguanosine

8-aza-guanosine

7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

Use of 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms