Rosamultic acid

Modify Date: 2024-01-04 15:56:48

Rosamultic acid Structure
Rosamultic acid structure
Common Name Rosamultic acid
CAS Number 214285-76-4 Molecular Weight 486.683
Density 1.2±0.1 g/cm3 Boiling Point 630.2±55.0 °C at 760 mmHg
Molecular Formula C30H46O5 Melting Point N/A
MSDS N/A Flash Point 348.9±28.0 °C

 Use of Rosamultic acid


Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing Apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases[1][2].

 Names

Name (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-11-Hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylic acid
Synonym More Synonyms

 Rosamultic acid Biological Activity

Description Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing Apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases[1][2].
Related Catalog
References

[1]. Yeo H, et al. A-ring contracted triterpenoid from Rosa multiflora[J]. Phytochemistry, 1998, 48(8):1399-1401.

[2]. Sui CG, et al. Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine. 2015 Aug 15;22(9):796-806.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 630.2±55.0 °C at 760 mmHg
Molecular Formula C30H46O5
Molecular Weight 486.683
Flash Point 348.9±28.0 °C
Exact Mass 486.334534
LogP 5.87
Vapour Pressure 0.0±4.2 mmHg at 25°C
Index of Refraction 1.593

 Synonyms

(3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-11-Hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylic acid
7aH-Cyclopenta[a]chrysene-7a-carboxylic acid, 3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-11-hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-, (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-