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214285-76-4

214285-76-4 structure
214285-76-4 structure
  • Name: Rosamultic acid
  • Chemical Name: (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-11-Hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylic acid
  • CAS Number: 214285-76-4
  • Molecular Formula: C30H46O5
  • Molecular Weight: 486.683
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-07-02 09:57:58
  • Modify Date: 2024-01-04 15:56:48
  • Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing Apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases[1][2].

Name (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-11-Hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylic acid
Synonyms (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-11-Hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylic acid
7aH-Cyclopenta[a]chrysene-7a-carboxylic acid, 3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-hexadecahydro-11-hydroxy-1,3-bis(hydroxymethyl)-3,5a,5b,10,11,13b-hexamethyl-, (3S,3aR,5aR,5bS,7aS,10R,11R,11aS,13aS,13bR)-
Description Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing Apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases[1][2].
Related Catalog
References

[1]. Yeo H, et al. A-ring contracted triterpenoid from Rosa multiflora[J]. Phytochemistry, 1998, 48(8):1399-1401.

[2]. Sui CG, et al. Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine. 2015 Aug 15;22(9):796-806.  

Density 1.2±0.1 g/cm3
Boiling Point 630.2±55.0 °C at 760 mmHg
Molecular Formula C30H46O5
Molecular Weight 486.683
Flash Point 348.9±28.0 °C
Exact Mass 486.334534
LogP 5.87
Vapour Pressure 0.0±4.2 mmHg at 25°C
Index of Refraction 1.593