WHI-P258

Modify Date: 2024-01-17 19:49:12

WHI-P258 structure	Common Name	WHI-P258
	CAS Number	21561-09-1	Molecular Weight	281.309
	Density	1.3±0.1 g/cm3	Boiling Point	441.2±40.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	220.6±27.3 °C

Use of WHI-P258

WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

Name	6,7-dimethoxy-N-phenylquinazolin-4-amine
Synonym	More Synonyms

Description	WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> JNK
References	[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> JNK

References

[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.

[2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

Density	1.3±0.1 g/cm3
Boiling Point	441.2±40.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅N₃O₂
Molecular Weight	281.309
Flash Point	220.6±27.3 °C
Exact Mass	281.116425
PSA	56.27000
LogP	2.87
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.663
Storage condition	-20℃