Z-Ile-Glu-Thr-Asp-AFC

Modify Date: 2024-01-07 22:24:58

Z-Ile-Glu-Thr-Asp-AFC structure	Common Name	Z-Ile-Glu-Thr-Asp-AFC
	CAS Number	219138-02-0	Molecular Weight	821.75000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₄₂F₃N₅O₁₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Z-Ile-Glu-Thr-Asp-AFC

Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1].

Name	Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin
Synonym	More Synonyms

Description	Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Boudard D, et al. Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. Leukemia. 2002;16(11):2343-2345.

Molecular Formula	C₃₇H₄₂F₃N₅O₁₃
Molecular Weight	821.75000
Exact Mass	821.27300
PSA	279.77000
LogP	3.90270
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro.

J. Biol. Chem. 272 , 13432-13436, (1997)

The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are proteolytically generate...

MFCD01318832

(4S)-5-[[(2S,3R)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoic acid

Cbz-IETD-AFC

Z-Ile-Glu-Thr-Asp-AFC

Z-IETD-AFC