Ac-Ile-Glu-Thr-Asp-pNA

Modify Date: 2024-01-12 19:36:38

Ac-Ile-Glu-Thr-Asp-pNA Structure
Ac-Ile-Glu-Thr-Asp-pNA structure
Common Name Ac-Ile-Glu-Thr-Asp-pNA
CAS Number 219138-21-3 Molecular Weight 638.624
Density 1.4±0.1 g/cm3 Boiling Point 1140.8±65.0 °C at 760 mmHg
Molecular Formula C27H38N6O12 Melting Point N/A
MSDS N/A Flash Point 643.7±34.3 °C

 Use of Ac-Ile-Glu-Thr-Asp-pNA


Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].

 Names

Name ac-ietd-pna
Synonym More Synonyms

 Ac-Ile-Glu-Thr-Asp-pNA Biological Activity

Description Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].
Related Catalog
References

[1]. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1140.8±65.0 °C at 760 mmHg
Molecular Formula C27H38N6O12
Molecular Weight 638.624
Flash Point 643.7±34.3 °C
Exact Mass 638.254761
PSA 286.15000
LogP 1.27
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.583

 Synonyms

ac-ietd-amc
z-ala-ala-asp-afc
N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)-L-α-asparagine
ac-ile-glu-thr-asp-mca
ac-ietd-mca
L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)-
pase-8 substrate
pase-8 substrate i
ac-ile-glu-thr-asp-amc
ax-ietd-amc
granzyme b substrate
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