Lp-PLA2-IN-3

Modify Date: 2024-01-11 13:40:16

Lp-PLA2-IN-3 structure	Common Name	Lp-PLA2-IN-3
	CAS Number	2196245-16-4	Molecular Weight	467.85
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₃ClF₃N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lp-PLA2-IN-3

Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)[1].

Name	Lp-PLA2-IN-3

Description	Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
In Vivo	Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively[1]. Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively[1]. Animal Model: Male Sprague−Dawley (SD) rats (180-220 g)[1] Dosage: 3 mg/kg Administration: p.o. (Pharmacokinetic Analysis) Result: The Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 6.2 μg h/mL, 7.7 hours and 35.5%, respectively.
References	[1]. Liu Q, et al. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J Med Chem. 2017 Dec 28;60(24):10231-10244.

Molecular Formula	C₂₀H₁₃ClF₃N₃O₃S
Molecular Weight	467.85

DC Chemicals Limited
China
Product Name: Lp-PLA2-IN-3
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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