ShK-Dap22

Modify Date: 2024-02-28 09:50:25

ShK-Dap22 Structure
ShK-Dap22 structure
Common Name ShK-Dap22
CAS Number 220384-25-8 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C166H268N54O48S7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ShK-Dap22


ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].

 Names

Name (Dap22)-Stichodactyla helianthus Neurotoxin (ShK)

 ShK-Dap22 Biological Activity

Description ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].
Related Catalog
In Vitro ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1].
References

[1]. K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707.

 Chemical & Physical Properties

Molecular Formula C166H268N54O48S7
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