220384-25-8

220384-25-8 structure

Name: ShK-Dap22
Chemical Name: (Dap22)-Stichodactyla helianthus Neurotoxin (ShK)
CAS Number: 220384-25-8
Molecular Formula: C₁₆₆H₂₆₈N₅₄O₄₈S₇
Molecular Weight:
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2016-09-11 08:11:26
Modify Date: 2024-02-28 09:50:25
ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].

Name	(Dap22)-Stichodactyla helianthus Neurotoxin (ShK)

Description	ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1].
References	[1]. K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707.

Molecular Formula	C₁₆₆H₂₆₈N₅₄O₄₈S₇