Diphyllin

Modify Date: 2024-01-08 10:47:54

Diphyllin structure	Common Name	Diphyllin
	CAS Number	22055-22-7	Molecular Weight	380.34800
	Density	1.445g/cm3	Boiling Point	638.8ºC at 760 mmHg
	Molecular Formula	C₂₁H₁₆O₇	Melting Point	290 ºC (methanol )
	MSDS	N/A	Flash Point	232.4ºC

Use of Diphyllin

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].

Name	9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one
Synonym	More Synonyms

Description	Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
Target	HIV-1:0.38 μM (IC50) Vesicular stomatitis virus (VSV) Vacuolar type H+-ATPase:17 nM (IC50)
References	[1]. Xin-Ya Xu, et al. Anti-HIV Lignans From Justicia Procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952. [2]. Mette G Sørensen, et al. Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption. J Bone Miner Res. 2007 Oct;22(10):1640-8. [3]. Yerra Koteswara Rao, et al. Anti-inflammatory Activities of Constituents Isolated From Phyllanthus Polyphyllus. J Ethnopharmacol. 2006 Jan 16;103(2):181-6.

Density	1.445g/cm3
Boiling Point	638.8ºC at 760 mmHg
Melting Point	290 ºC (methanol )
Molecular Formula	C₂₁H₁₆O₇
Molecular Weight	380.34800
Flash Point	232.4ºC
Exact Mass	380.09000
PSA	83.45000
LogP	3.62870
Vapour Pressure	6.53E-17mmHg at 25°C
Index of Refraction	1.679
Storage condition	2-8℃
Water Solubility	Insuluble (2.4E-3 g/L) (25 ºC)

Precursor 6
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DownStream 1
CAS#:25001-57-4 justicidin A