![]() JH-VIII-49 structure
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Common Name | JH-VIII-49 | ||
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CAS Number | 2209084-73-9 | Molecular Weight | 428.664 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C30H40N2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of JH-VIII-49JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM). |
Name | JH-VIII-49 |
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Description | JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM). |
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References | References 1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011 View Related Products by Target Cyclin-dependent Kinase (CDK) |
Molecular Formula | C30H40N2 |
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Molecular Weight | 428.664 |