2209085-22-1

2209085-22-1 structure

Name: JH-XI-10-02
Chemical Name: JH-XI-10-02
CAS Number: 2209085-22-1
Molecular Formula: C₅₃H₆₉N₅O₉
Molecular Weight: 920.14
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-03-30 14:05:33
Modify Date: 2024-01-10 17:15:24
JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].

Name	JH-XI-10-02

Description	JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK8:159 nM (IC50) PROTAC
References	[1]. Hatcher JM, et al. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545.

Molecular Formula	C₅₃H₆₉N₅O₉
Molecular Weight	920.14

Hazard Codes	Xi