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  • DC Chemicals Limited
  • China
  • Product Name: JH-XVI-178
  • Price: $Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

2648453-53-4

2648453-53-4 structure
2648453-53-4 structure
  • Name: JH-XVI-178
  • Chemical Name: JH-XVI-178
  • CAS Number: 2648453-53-4
  • Molecular Formula: C22H22ClN7O
  • Molecular Weight: 435.91
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2021-12-23 14:20:35
  • Modify Date: 2024-01-19 20:04:11
  • JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.

Name JH-XVI-178
Description JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.
Related Catalog
Target

CDK8:1 nM (IC50)

CDK19:2 nM (IC50)

References

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693.

Molecular Formula C22H22ClN7O
Molecular Weight 435.91