Diflomotecan

Modify Date: 2024-01-20 16:59:09

Diflomotecan Structure
Diflomotecan structure
Common Name Diflomotecan
CAS Number 220997-97-7 Molecular Weight 398.359
Density 1.6±0.1 g/cm3 Boiling Point 784.2±60.0 °C at 760 mmHg
Molecular Formula C21H16F2N2O4 Melting Point N/A
MSDS N/A Flash Point 428.1±32.9 °C

 Use of Diflomotecan


Diflomotecan (BN 80915) is a potent inhibitor of topoisomerase I. Diflomotecan causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds[1].

 Names

Name diflomotecan
Synonym More Synonyms

 Diflomotecan Biological Activity

Description Diflomotecan (BN 80915) is a potent inhibitor of topoisomerase I. Diflomotecan causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds[1].
Related Catalog
Target

topoisomerase I[1]

References

[1]. Kroep JR, et al. Diflomotecan, a promising homocamptothecin for cancer therapy. Expert Opin Investig Drugs. 2009;18(1):69-75.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 784.2±60.0 °C at 760 mmHg
Molecular Formula C21H16F2N2O4
Molecular Weight 398.359
Flash Point 428.1±32.9 °C
Exact Mass 398.107819
LogP 1.73
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.696

 Synonyms

diflomotecan
QKT1LC4J1P
3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-
3H,15H-Oxepino(3',4':6,7)indolizino(1,2-b)quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-
(5R)-5-Ethyl-9,10-difluoro-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione