LOXO-292

Modify Date: 2024-01-05 14:05:07

LOXO-292 Structure
LOXO-292 structure
Common Name LOXO-292
CAS Number 2222755-14-6 Molecular Weight 553.61
Density N/A Boiling Point N/A
Molecular Formula C29H31N9O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LOXO-292


RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].

 Names

Name RET-IN-1
Synonym More Synonyms

 LOXO-292 Biological Activity

Description RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].
Related Catalog
Target

IC50: 1 nM (RETWT), 7 nM (RETV804M), 101 nM (RETG810R)

References

[1]. Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

 Chemical & Physical Properties

Molecular Formula C29H31N9O3
Molecular Weight 553.61
Storage condition 2-8℃

 Synonyms

LOXO-292
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