PKCiota-IN-1

Modify Date: 2024-04-06 10:51:13

PKCiota-IN-1 structure	Common Name	PKCiota-IN-1
	CAS Number	2230052-97-6	Molecular Weight	427.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₂FN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PKCiota-IN-1

PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].

Name	PKCiota-IN-1

Description	PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCι:2.7 nM (IC50) PKCα:45 nM (IC50) PKCε:450 nM (IC50)
References	[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.

Molecular Formula	C₂₅H₂₂FN₅O
Molecular Weight	427.47