2230052-97-6

2230052-97-6 structure
2230052-97-6 structure
  • Name: PKCiota-IN-1
  • Chemical Name: PKCiota-IN-1
  • CAS Number: 2230052-97-6
  • Molecular Formula: C25H22FN5O
  • Molecular Weight: 427.47
  • Catalog: Signaling Pathways Epigenetics PKC
  • Create Date: 2023-04-07 10:49:57
  • Modify Date: 2024-04-06 10:51:13
  • PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].

Name PKCiota-IN-1
Description PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].
Related Catalog
Target

PKCι:2.7 nM (IC50)

PKCα:45 nM (IC50)

PKCε:450 nM (IC50)

References

[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.  

Molecular Formula C25H22FN5O
Molecular Weight 427.47