N-piperidine Ibrutinib hydrochloride
Modify Date: 2024-01-14 11:07:28
N-piperidine Ibrutinib hydrochloride structure
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Common Name | N-piperidine Ibrutinib hydrochloride | ||
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| CAS Number | 2231747-18-3 | Molecular Weight | 422.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-piperidine Ibrutinib hydrochlorideN-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2]. |
| Name | N-piperidine Ibrutinib hydrochloride |
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| Description | N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2]. |
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| Related Catalog | |
| Target |
IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK)[1] |
| In Vitro | N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC50s of 374, 162, and 8.3 nM, respectively[2]. |
| References |
| Molecular Formula | C22H23ClN6O |
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| Molecular Weight | 422.91 |